Yes, we have gathered five different mouse models for peanut allergy.
1. CT-Peanut induced Anaphylaxis
2. SEB_Peanut induced Anaphylaxis
3. Adjuvant free Peanut induced sensitisation
4. CT_Peanut induced anaphylaxis in C3H/HeJ
5. Humanized Peanut induced anaphylaxis model
Click here for the Mousemodels Peanut allergy
Peanut allergy is a prevalent food allergy affecting a significant portion of the global population. Currently, 1-2% of people worldwide have this allergy, with a growing number of affected children in the US, Europe, and Australia. In the past decade, the prevalence of peanut allergy among children has doubled, which is concerning as the condition typically persists into adulthood. While symptoms of this allergy are usually mild to moderate, they can sometimes be severe and life-threatening, particularly in individuals who are highly sensitive. Even the smallest amount of peanut protein can trigger an allergic reaction in these patients. Oral ingestion is the most common method of exposure, but inhalation or skin contact can also cause symptoms. The reaction to peanut allergens is initiated by specific IgE antibodies that bind to receptors on the surface of mast cells and basophils. The crosslinking of these receptors by peanut protein can lead to mast cell and basophil degranulation, resulting in a range of allergic symptoms, including potentially fatal anaphylaxis.